Endocrine Abstracts

The well characterized sodium iodide symporter (NIS) in its dual function as reporter and therapy gene displays an outstanding opportunity to target different cancer types allowing non-invasive imaging of functional NIS expression and therapeutic radionuclide application. We recently reported induction of tumor-selective accumulation and therapeutic efficacy of radioiodide after systemic non-viral epidermal growth factor receptor (EGFR)-targeted NIS gene delivery in a subcutan...